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Mike-Andrew Westhoff Selected Research

navitoclax

8/2021Photodynamic Therapy Combined with Bcl-2/Bcl-xL Inhibition Increases the Noxa/Mcl-1 Ratio Independent of Usp9X and Synergistically Enhances Apoptosis in Glioblastoma.
8/2020Epigenetic Targeting of Mcl-1 Is Synthetically Lethal with Bcl-xL/Bcl-2 Inhibition in Model Systems of Glioblastoma.
10/2019Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl-xL inhibition.
10/2018Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems.
1/2018Inhibition of Bcl-2/Bcl-xL and c-MET causes synthetic lethality in model systems of glioblastoma.
6/2016Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo.
3/2016Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo.
11/2015TIC10/ONC201 synergizes with Bcl-2/Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo.
6/2015Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo.

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Mike-Andrew Westhoff Research Topics

Disease

43Glioblastoma (Glioblastoma Multiforme)
02/2022 - 11/2005
37Neoplasms (Cancer)
02/2022 - 11/2005
10Glioma (Gliomas)
08/2021 - 03/2015
5Brain Neoplasms (Brain Tumor)
01/2021 - 12/2013
3Neuroblastoma
01/2014 - 11/2005
2Medulloblastoma
01/2022 - 01/2021
2Necrosis
03/2015 - 02/2014
1Starvation
01/2021
1Melanoma (Melanoma, Malignant)
10/2019
1Carcinoma (Carcinomatosis)
10/2019
1Colonic Neoplasms (Colon Cancer)
11/2018
1Cognitive Dysfunction
01/2018
1Diffuse Intrinsic Pontine Glioma
01/2018
1Infections
12/2017
1Neoplasm Metastasis (Metastasis)
03/2017
1Inflammation (Inflammations)
11/2016
1Leukemia
11/2015

Drug/Important Bio-Agent (IBA)

12Temozolomide (Temodar)FDA LinkGeneric
02/2022 - 02/2014
9navitoclaxIBA
08/2021 - 06/2015
8Pharmaceutical PreparationsIBA
01/2021 - 08/2008
6Proteins (Proteins, Gene)FDA Link
08/2021 - 01/2014
4Biological ProductsIBA
08/2021 - 06/2014
3AcidsIBA
02/2022 - 11/2018
3TIC10 compoundIBA
01/2021 - 11/2015
3Drug CombinationsIBA
11/2018 - 02/2014
2Glucose (Dextrose)FDA LinkGeneric
06/2021 - 01/2021
2CarbonIBA
06/2021 - 10/2019
2Deoxyglucose (2 Deoxy D glucose)IBA
01/2021 - 01/2020
2PanobinostatIBA
10/2020 - 01/2018
2Histone Deacetylases (Histone Deacetylase)IBA
10/2020 - 01/2018
2Phosphotransferases (Kinase)IBA
01/2020 - 08/2018
2CrizotinibIBA
01/2020 - 01/2018
2OTX015IBA
01/2018 - 06/2017
2Transcription Factors (Transcription Factor)IBA
06/2017 - 12/2013
2Cathepsin GIBA
11/2016 - 03/2016
2Histocompatibility Antigens Class IIBA
11/2016 - 03/2016
2Indicators and Reagents (Reagents)IBA
06/2016 - 03/2016
2Deubiquitinating EnzymesIBA
03/2016 - 11/2015
2Doxorubicin (Adriamycin)FDA LinkGeneric
01/2013 - 08/2008
1dinaciclibIBA
02/2022
1isothiocyanic acidIBA
02/2022
1Cyclin-Dependent Kinases (cdk Proteins)IBA
02/2022
1Meclofenamic Acid (Meclofenamate)FDA LinkGeneric
11/2021
11-phenyl-3,3-dimethyltriazene (PDT)IBA
08/2021
1Lactic Acid (Lactate)FDA LinkGeneric
06/2021
1Lomustine (CCNU)FDA Link
02/2021
1MethyltransferasesIBA
02/2021
1Ion Channels (Ion Channel)IBA
02/2021
1mRNA VaccinesIBA
01/2021
1Peptides (Polypeptides)IBA
01/2021
1Immunologic Factors (Immunomodulators)IBA
01/2021
1Aurora Kinase AIBA
01/2021
1romidepsin (FK228)FDA Link
10/2020
1Small Interfering RNA (siRNA)IBA
01/2020
1Histone Deacetylase InhibitorsIBA
01/2020
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2020
1Fatty Acids (Saturated Fatty Acids)IBA
01/2020
1Liver X ReceptorsIBA
10/2019
1GW 3965IBA
10/2019
1CholesterolIBA
10/2019
12- (2- chloro- 4- fluorobenzyl)- 3- (4- fluorophenyl)- 7- (trifluoromethyl)- 2H- indazoleIBA
10/2019
1Alkylating AgentsIBA
09/2019
1ONC212IBA
11/2018
1IsothiocyanatesIBA
11/2018
1Biomarkers (Surrogate Marker)IBA
11/2018
1ONC206IBA
11/2018
1Initiator CaspasesIBA
10/2018
1selinexorIBA
10/2018
1Sorafenib (BAY 43-9006)FDA Link
01/2018
1Adenosine Triphosphate (ATP)IBA
01/2018
1DapsoneFDA Link
12/2017
1SulfonesIBA
12/2017
1Anti-Bacterial Agents (Antibiotics)IBA
12/2017
1CathepsinsIBA
03/2017
1Peptide Hydrolases (Proteases)FDA Link
03/2017
1LactoferrinIBA
11/2016
1Serine Proteases (Serine Protease)IBA
11/2016
1Asparaginase (Elspar)FDA Link
06/2016
1Amino AcidsFDA Link
06/2016
1degrasynIBA
03/2016
1obatoclaxIBA
06/2015
1BH 3IBA
06/2015
1Olanzapine (Zyprexa)FDA Link
03/2015
1Antipsychotic Agents (Antipsychotics)IBA
03/2015
1Irinotecan (Camptosar)FDA LinkGeneric
02/2015
1Sunitinib (Sutent)FDA Link
02/2015
12- (1H- indazol- 4- yl)- 6- (4- methanesulfonylpiperazin- 1- ylmethyl)- 4- morpholin- 4- ylthieno(3,2- d)pyrimidineIBA
02/2015
1Sirolimus (Rapamycin)FDA Link
02/2015
1Activating Transcription Factor 4IBA
06/2014
1Phosphatidylinositols (Phosphatidylinositol)IBA
06/2014
1Glutathione (Reduced Glutathione)IBA
06/2014
1Cysteine (L-Cysteine)FDA Link
06/2014

Therapy/Procedure

35Therapeutics
02/2022 - 01/2013
7Drug Therapy (Chemotherapy)
11/2018 - 08/2008
6Radiotherapy
01/2021 - 01/2017
2Immunotherapy
01/2021 - 08/2018
1Photochemotherapy (Photodynamic Therapy)
08/2021
1Stem Cell Transplantation
01/2021
1Drug Tapering
01/2019
1Precision Medicine
08/2018